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Circularity

Parameter changes such as buffer formulation, dilution, or encapsulated drugs, can affect the morphology of membranous carriers such as liposomes.

These changes can be monitored and evaluated by measuring the circularity (or elongatedness) of the particles, providing insights into the efficacy and stability of the product.

Circularity for web

Circularity histogram

Monitor your particles morphology

At QuTEM,  we offer a comprehensive analytical solution for assessing morphological changes during bioprocessing. With our advanced image analysis software, we provide objective and quantitative statistics on the circularity of drug products with the possibility to monitor this parameter over several months or years.

Examples

At QuTEM, the circularity assessment is typically performed for the following particle types:

Innovative analysis

Our analysis workflow includes:

  • Particle detection
  • Particle classification
  • Generation of a comprehensive report
liposome-original
liposome-detected

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