Extracellular vesicles
Extracellular vesicles (EVs), a broad term encompassing vesicles secreted by various cells, have emerged as promising drug carriers in gene therapies and vaccines. The composition of EV products can be influenced by factors like their cellular origin, manufacturing, and purification processes. Characterizing such products is challenging, but a visualization method with high resolution proves invaluable. Â
Transmission Electron Microscopy (TEM) emerges as a reliable tool in this regard. It enables the identification of intact particles and analysis of size distribution and encapsulation efficiency, offering insights into product bioactivity. Moreover, TEM facilitates the monitoring of integrity, purity, and aggregation of EVs during manufacturing for lot comparison and stability studies. Â
Analyses
At QuTEM, we generally offer the following analyses for EVs.
Monitor the quality of EVs throughout the manufacturing process
- Assess the purity of the EV samples with nsTEM (left)
- Reveal the internal structures of the EVs through cryoTEM (right)
Example report
Download an example report that includes:
- Analysis of an exosome sample by cryoTEM
Example report
Download an example report that includes:
- Analysis of an exosome sample by nsTEM
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