Aggregation
Our experts perform a quantitative analysis of viral particles aggregation on TEM images with the help of our proprietary software, which semi-automatically detects and classifies individual particles and aggregates.
This insight is crucial for optimizing the stability and efficacy of virus-based vaccines and gene therapy products. Aggregation can be best seen by nsTEM.
Size distribution histogram of aggregates
Evaluate your production efficacy
At QuTEM, we offer the ability to use our analytical tools to monitor clusters and aggregates of your sample over time. Individual particles and clusters/aggregates can be quantified by total number particles or as a percentage ratio of a sample.
Examples
At QuTEM, the aggregation analysis is typically performed for the following particle types:
Innovative analysis methods
Our analysis workflow includes:
- Particle detection
- Particle classification
- Generation of a comprehensive report
Webinar - AAV Aggregation analysis
Check our recorded webinar on A new approach to AAV aggregation analysis, with two distinct approaches discussed:
- A classification approach, where aggregates and individual particles are directly segmented on the image.
- A statistical approach, where the distance from each particle to its nearest neighbors is measured and compared to a theoretical value to identify true aggregation events.
Example reports
Download an example report that includes:
- Analysis of an AAV sample by nsTEM
- Size analysis and aggregation evaluation
