Learning center
method
New approaches to aggregation analysis by CryoTEM
Particle aggregation is a critical attribute across biologics, viral vectors, and nanoparticle-based systems. Even low levels of aggregation may influence product stability, biological activity, immunogenicity risk, and batch consistency.
Conventional b...
Peer-reviewed paper
research paper
AAV Vector Characterization with Quantitative TEM
Accurate characterization of AAV vector content is a critical quality attribute in gene therapy development and manufacturing. In this study, we validated Quantitative Transmission Electron Microscopy (QuTEM) as a robust method for single-particle class...
lentiviral vectors
Webinar
A new approach to AAV aggregation analysis
Check our recorded webinar on A new approach to AAV aggregation analysis !
In this webinar, our Chief Operating Officer, Rickard Nordström, discusses how TEM serves as a powerful tool for aggregation analysis and shares insights on our newly develop me...
AAV
genome length
vector content
White paper
White paper – AAV Genome Length Determination
This white paper presents QuTEM’s advanced analysis, offering precise characterization of for (AAV) capsids. Our validated platform leverages cryo-TEM imaging and density measurements to distinguish and quantify empty , partially filled, filled...
lentiviral vectors
Webinar
TEM Analysis of Lentivirus for Quality Control
Check our recorded webinar on TEM Analysis of Lentivirus for Quality Control!
In this video, Mathieu Colomb-Delsuc. Senior Scientist at QuTEM, discusses how TEM serves as a powerful tool for analyzing critical quality attributes of lentivirus In this we...
AAV
genome length
vector content
Webinar
White paper
TEM analysis of AAVs for quality control
Recorded webinar
Genome length determination
In this webinar, our COO, Rickard Nordström dived into the technical aspects of our latest method (Generation 3) for determining both the full-to-empty ratio and genome length of AAVs. With this advanc...